Zusammenfassung
Objective Transforming growth factor-beta 1 (TGF beta 1) is a short-lived immune suppressive and profibrotic protein. Its latent precursor is relatively stable and may even protect from fibrosis. Latent TGF beta 1 is synthesized by various tissues including the liver and portal, hepatic, and systemic concentrations of latent TGF beta 1 were determined in patients with liver cirrhosis and patients ...
Zusammenfassung
Objective Transforming growth factor-beta 1 (TGF beta 1) is a short-lived immune suppressive and profibrotic protein. Its latent precursor is relatively stable and may even protect from fibrosis. Latent TGF beta 1 is synthesized by various tissues including the liver and portal, hepatic, and systemic concentrations of latent TGF beta 1 were determined in patients with liver cirrhosis and patients with normal liver function to find out whether circulating levels are affected by liver disease. Methods Latent TGF beta 1 was measured in portal venous serum (PVS), hepatic venous serum (HVS), and systemic venous serum (SVS) of 26 patients with liver cirrhosis and nine patients with normal liver function. Results Latent TGF beta 1 was similarly abundant in HVS, PVS, and SVS of patients with liver cirrhosis and controls. There was a strong positive correlation of HVS, PVS, and SVS TGF beta 1 to each other. PVS levels of latent TGF beta 1 were significantly lower in patients with CHILD-PUGH stage C compared with CHILD-PUGH stage A, SVS levels were modestly and HVS levels tended to be reduced. PVS and SVS TGF beta 1 concentrations were also lower in patients with a higher model for end-stage liver disease score. Only PVS concentrations were reduced in patients with massive ascites compared with the patients without ascites. Creatinine clearance as a marker of renal function and parameters of coagulation did not correlate with this cytokine indicating that latent TGF beta 1 levels are not linked to kidney function and coagulation. Interleukin-6, which is elevated in patients with liver cirrhosis negatively correlated with latent TGF beta 1 in PVS and SVS. Conclusion In patients with liver cirrhosis splanchnic organ-derived latent TGF beta 1 is negatively associated with the liver function. Eur J Gastroenterol Hepatol 23: 218-223 (C) 2011 Wolters Kluwer Health vertical bar Lippincott Williams & Wilkins.
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