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Histone H2A C-Terminus Regulates Chromatin Dynamics, Remodeling, and Histone H1 Binding

Ferguson-Smith, Anne C. ; Vogler, Christine ; Huber, Claudia ; Waldmann, Tanja ; Ettig, Ramona ; Braun, Lora ; Izzo, Annalisa ; Daujat, Sylvain ; Chassignet, Isabelle ; Lopez-Contreras, Andres Joaquin ; Fernandez-Capetillo, Oscar ; Dundr, Miroslav ; Rippe, Karsten ; Längst, Gernot ; Schneider, Robert



Abstract

The tails of histone proteins are central players for all chromatin-mediated processes. Whereas the N-terminal histone tails have been studied extensively, little is known about the function of the H2A C-terminus. Here, we show that the H2A C-terminal tail plays a pivotal role in regulating chromatin structure and dynamics. We find that cells expressing C-terminally truncated H2A show increased ...

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