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Journal or Publication Title: | Nature Genetics | ||||
Publisher: | NATURE PUBLISHING GROUP | ||||
Place of Publication: | NEW YORK | ||||
Volume: | 42 | ||||
Number of Issue or Book Chapter: | 11 | ||||
Page Range: | pp. 949-960 | ||||
Date: | 2010 | ||||
Institutions: | Medicine > Lehrstuhl für Innere Medizin II Medicine > Institut für Epidemiologie und Präventivmedizin | ||||
Identification Number: |
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Keywords: | GENOME-WIDE ASSOCIATION; CORONARY-HEART-DISEASE; BODY-FAT; METABOLIC RISK; ABDOMINAL ADIPOSITY; GLUCOSE-HOMEOSTASIS; SUSCEPTIBILITY LOCI; INSULIN-RESISTANCE; COMMON VARIANTS; OBESITY; | ||||
Dewey Decimal Classification: | 600 Technology > 610 Medical sciences Medicine | ||||
Status: | Published | ||||
Refereed: | Yes, this version has been refereed | ||||
Created at the University of Regensburg: | Yes | ||||
Item ID: | 65645 |
Abstract
Waist-hip ratio (WHR) is a measure of body fat distribution and a predictor of metabolic consequences independent of overall adiposity. WHR is heritable, but few genetic variants influencing this trait have been identified. We conducted a meta-analysis of 32 genome-wide association studies for WHR adjusted for body mass index (comprising up to 77,167 participants), following up 16 loci in an ...

Abstract
Waist-hip ratio (WHR) is a measure of body fat distribution and a predictor of metabolic consequences independent of overall adiposity. WHR is heritable, but few genetic variants influencing this trait have been identified. We conducted a meta-analysis of 32 genome-wide association studies for WHR adjusted for body mass index (comprising up to 77,167 participants), following up 16 loci in an additional 29 studies (comprising up to 113,636 subjects). We identified 13 new loci in or near RSPO3, VEGFA, TBX15-WARS2, NFE2L3, GRB14, DNM3-PIGC, ITPR2-SSPN, LY86, HOXC13, ADAMTS9, ZNRF3-KREMEN1, NISCH-STAB1 and CPEB4 (P = 1.9 x 10(-9) to P = 1.8 x 10(-40)) and the known signal at LYPLAL1. Seven of these loci exhibited marked sexual dimorphism, all with a stronger effect on WHR in women than men (P for sex difference = 1.9 x 10(-3) to P = 1.2 x 10(-13)). These findings provide evidence for multiple loci that modulate body fat distribution independent of overall adiposity and reveal strong gene-by-sex interactions.
Metadata last modified: 19 Dec 2024 11:31