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Genome-wide association study identifies new HLA class II haplotypes strongly protective against narcolepsy

Hor, Hyun ; Kutalik, Zoltán ; Dauvilliers, Yves ; Valsesia, Armand ; Lammers, Gert J ; Donjacour, Claire E H M ; Iranzo, Alex ; Santamaria, Joan ; Peraita Adrados, Rosa ; Vicario, José L ; Overeem, Sebastiaan ; Arnulf, Isabelle ; Theodorou, Ioannis ; Jennum, Poul ; Knudsen, Stine ; Bassetti, Claudio ; Mathis, Johannes ; Lecendreux, Michel ; Mayer, Geert ; Geisler, Peter ; Benetó, Antonio ; Petit, Brice ; Pfister, Corinne ; Bürki, Julie Vienne ; Didelot, Gérard ; Billiard, Michel ; Ercilla, Guadalupe ; Verduijn, Willem ; Claas, Frans H J ; Vollenweider, Peter ; Waeber, Gerard ; Waterworth, Dawn M ; Mooser, Vincent ; Heinzer, Raphaël ; Beckmann, Jacques S ; Bergmann, Sven ; Tafti, Mehdi



Zusammenfassung

Narcolepsy is a rare sleep disorder with the strongest human leukocyte antigen (HLA) association ever reported. Since the associated HLA-DRB1*1501-DQB1*0602 haplotype is common in the general population (15-25%), it has been suggested that it is almost necessary but not sufficient for developing narcolepsy. To further define the genetic basis of narcolepsy risk, we performed a genome-wide ...

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