Kleiter, Ingo ; Schröder, Michael ; Lürding, Ralf ; Schuierer, Gerhard ; Clifford, David B ; Bogdahn, Ulrich ; Steinbrecher, Andreas ; Pöschl, Peter
Alternative Links zum Volltext:DOIVerlag
| Dokumentenart: | Artikel |
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| Titel eines Journals oder einer Zeitschrift: | Multiple Sclerosis Journal |
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| Verlag: | SAGE PUBLICATIONS LTD |
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| Ort der Veröffentlichung: | LONDON |
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| Band: | 16 |
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| Nummer des Zeitschriftenheftes oder des Kapitels: | 6 |
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| Seitenbereich: | S. 749-753 |
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| Datum: | 2010 |
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| Institutionen: | Medizin > Lehrstuhl für Neurologie |
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| Identifikationsnummer: | | Wert | Typ |
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| 10.1177/1352458510367718 | DOI |
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| Stichwörter / Keywords: | MULTIPLE-SCLEROSIS; electroencphalography; multiple sclerosis; natalizumab; MRI; progressive multifocal leucoencephalopathy |
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| Dewey-Dezimal-Klassifikation: | 600 Technik, Medizin, angewandte Wissenschaften > 610 Medizin |
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| Status: | Veröffentlicht |
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| Begutachtet: | Ja, diese Version wurde begutachtet |
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| An der Universität Regensburg entstanden: | Ja |
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| Dokumenten-ID: | 66089 |
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Web of Science
Zusammenfassung
Progressive multifocal leucoencephalopathy has become a growing concern in natalizumab-treated multiple sclerosis patients. Here, we describe a 35-year-old patient who was treated with 34 infusions of natalizumab before complaining about visual deterioration. MRI was non-diagnostic and JC virus testing initially was negative. Electroencephalography showed severe slowing of the right hemisphere, ...
Zusammenfassung
Progressive multifocal leucoencephalopathy has become a growing concern in natalizumab-treated multiple sclerosis patients. Here, we describe a 35-year-old patient who was treated with 34 infusions of natalizumab before complaining about visual deterioration. MRI was non-diagnostic and JC virus testing initially was negative. Electroencephalography showed severe slowing of the right hemisphere, and neuropsychological testing revealed right frontal and temporal deficits. The diagnosis of progressive multifocal leucoencephalopathy was established 2 months later by typical MRI presentation and detection of JC virus DNA in the cerebrospinal fluid. Functional neurological deficits may precede imaging features and should prompt early consideration of progressive multifocal leucoencephalopathy.
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