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A prospective randomised, open-labeled, trial comparing sirolimus-containing versus mTOR-inhibitor-free immunosuppression in patients undergoing liver transplantation for hepatocellular carcinoma

Schnitzbauer, Andreas A ; Zuelke, Carl ; Graeb, Christian ; Rochon, Justine ; Bilbao, Itxarone ; Burra, Patrizia ; de Jong, Koert P ; Duvoux, Christophe ; Kneteman, Norman M ; Adam, Rene ; Bechstein, Wolf O ; Becker, Thomas ; Beckebaum, Susanne ; Chazouillères, Olivier ; Cillo, Umberto ; Colledan, Michele ; Fändrich, Fred ; Gugenheim, Jean ; Hauss, Johann P ; Heise, Michael ; Hidalgo, Ernest ; Jamieson, Neville ; Königsrainer, Alfred ; Lamby, Philipp E ; Lerut, Jan P ; Mäkisalo, Heikki ; Margreiter, Raimund ; Mazzaferro, Vincenzo ; Mutzbauer, Ingrid ; Otto, Gerd ; Pageaux, Georges-Philippe ; Pinna, Antonio D ; Pirenne, Jacques ; Rizell, Magnus ; Rossi, Giorgio ; Rostaing, Lionel ; Roy, Andre ; Turrion, Victor Sanchez ; Schmidt, Jan ; Troisi, Roberto I ; van Hoek, Bart ; Valente, Umberto ; Wolf, Philippe ; Wolters, Heiner ; Mirza, Darius F ; Scholz, Tim ; Steininger, Rudolf ; Soderdahl, Gunnar ; Strasser, Simone I ; Jauch, Karl-Walter ; Neuhaus, Peter ; Schlitt, Hans J ; Geissler, Edward K



Zusammenfassung

Background: The potential anti-cancer effects of mammalian target of rapamycin (mTOR) inhibitors are being intensively studied. To date, however, few randomised clinical trials (RCT) have been performed to demonstrate antineoplastic effects in the pure oncology setting, and at present, no oncology endpoint-directed RCT has been reported in the high-malignancy risk population of immunosuppressed ...

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