; Olden, Matthias ; Glazer, Nicole L ; Parsa, Afshin ; Gao, Xiaoyi ; Yang, Qiong ; Smith, Albert V
; O'Connell, Jeffrey R ; Li, Man
; Schmidt, Helena ; Tanaka, Toshiko ; Isaacs, Aaron ; Ketkar, Shamika ; Hwang, Shih-Jen ; Johnson, Andrew D ; Dehghan, Abbas
; Teumer, Alexander ; Paré, Guillaume
; Atkinson, Elizabeth J ; Zeller, Tanja ; Lohman, Kurt ; Cornelis, Marilyn C ; Probst-Hensch, Nicole M ; Kronenberg, Florian
; Tönjes, Anke ; Hayward, Caroline
; Aspelund, Thor
; Eiriksdottir, Gudny ; Launer, Lenore J ; Harris, Tamara B ; Rampersaud, Evadnie ; Mitchell, Braxton D
; Arking, Dan E ; Boerwinkle, Eric ; Struchalin, Maksim ; Cavalieri, Margherita ; Singleton, Andrew ; Giallauria, Francesco
; Metter, Jeffrey ; de Boer, Ian H ; Haritunians, Talin ; Lumley, Thomas ; Siscovick, David ; Psaty, Bruce M ; Zillikens, M Carola ; Oostra, Ben A ; Feitosa, Mary
; Province, Michael ; de Andrade, Mariza ; Turner, Stephen T ; Schillert, Arne ; Ziegler, Andreas
; Wild, Philipp S ; Schnabel, Renate B ; Wilde, Sandra ; Munzel, Thomas F ; Leak, Tennille S ; Illig, Thomas ; Klopp, Norman ; Meisinger, Christa
; Wichmann, H-Erich ; Koenig, Wolfgang ; Zgaga, Lina
; Zemunik, Tatijana ; Kolcic, Ivana
; Minelli, Cosetta ; Hu, Frank B ; Johansson, Åsa
; Igl, Wilmar ; Zaboli, Ghazal ; Wild, Sarah H ; Wright, Alan F ; Campbell, Harry ; Ellinghaus, David ; Schreiber, Stefan
; Aulchenko, Yurii S
; Felix, Janine F
; Rivadeneira, Fernando
; Uitterlinden, Andre G ; Hofman, Albert ; Imboden, Medea ; Nitsch, Dorothea ; Brandstätter, Anita ; Kollerits, Barbara ; Kedenko, Lyudmyla ; Mägi, Reedik ; Stumvoll, Michael ; Kovacs, Peter ; Boban, Mladen
; Campbell, Susan ; Endlich, Karlhans
; Völzke, Henry ; Kroemer, Heyo K ; Nauck, Matthias ; Völker, Uwe ; Polasek, Ozren
; Vitart, Veronique ; Badola, Sunita ; Parker, Alexander N ; Ridker, Paul M ; Kardia, Sharon L R ; Blankenberg, Stefan ; Liu, Yongmei ; Curhan, Gary C ; Franke, Andre
; Rochat, Thierry ; Paulweber, Bernhard ; Prokopenko, Inga
; Wang, Wei ; Gudnason, Vilmundur
; Shuldiner, Alan R
; Coresh, Josef ; Schmidt, Reinhold ; Ferrucci, Luigi ; Shlipak, Michael G ; van Duijn, Cornelia M ; Borecki, Ingrid ; Krämer, Bernhard K ; Rudan, Igor
; Gyllensten, Ulf ; Wilson, James F
; Witteman, Jacqueline C ; Pramstaller, Peter P ; Rettig, Rainer ; Hastie, Nick ; Chasman, Daniel I ; Kao, W H ; Heid, Iris M ; Fox, Caroline S | Item type: | Article | ||||
|---|---|---|---|---|---|
| Journal or Publication Title: | Nature Genetics | ||||
| Publisher: | NATURE PUBLISHING GROUP | ||||
| Place of Publication: | NEW YORK | ||||
| Volume: | 42 | ||||
| Number of Issue or Book Chapter: | 5 | ||||
| Page Range: | pp. 376-384 | ||||
| Date: | 2010 | ||||
| Institutions: | Medicine > Institut für Epidemiologie und Präventivmedizin | ||||
| Identification Number: |
| ||||
| Keywords: | GENOME-WIDE ASSOCIATION; GLOMERULAR-FILTRATION-RATE; SERUM CREATININE; ALSTROM-SYNDROME; HYPERTROPHIC CARDIOMYOPATHY; PROXIMAL TUBULE; BLOOD-PRESSURE; PROTEIN; GENE; EXPRESSION; | ||||
| Dewey Decimal Classification: | 600 Technology > 610 Medical sciences Medicine | ||||
| Status: | Published | ||||
| Refereed: | Yes, this version has been refereed | ||||
| Created at the University of Regensburg: | Yes | ||||
| Item ID: | 66166 |
Abstract
Chronic kidney disease (CKD) is a significant public health problem, and recent genetic studies have identified common CKD susceptibility variants. The CKDGen consortium performed a meta-analysis of genome-wide association data in 67,093 individuals of European ancestry from 20 predominantly population-based studies in order to identify new susceptibility loci for reduced renal function as ...

Abstract
Chronic kidney disease (CKD) is a significant public health problem, and recent genetic studies have identified common CKD susceptibility variants. The CKDGen consortium performed a meta-analysis of genome-wide association data in 67,093 individuals of European ancestry from 20 predominantly population-based studies in order to identify new susceptibility loci for reduced renal function as estimated by serum creat-inine (eGFRcrea), serum cystatin c (eGFRcys) and CKD (eGFRcrea < 60 ml/min/ 1.73 m(2); n = 5,807 individuals with CKD (cases)). Follow-up of the 23 new genome-wide-significant loci (P < 5 x 10(-8)) in 22,982 replication samples identified 13 new loci affecting renal function and CKD (in or near LASS2, GCKR, ALMS1, TFDP2, DAB2, SLC34A1, VEGFA, PRKAG2, PIP5K1B, ATXN2, DACH1, UBE2Q2 and SLC7A9) and 7 loci suspected to affect creatinine production and secretion (CPS1, SLC22A2, TMEM60, WDR37, SLC6A13, WDR72 and BCAS3). These results further our understanding of the biologic mechanisms of kidney function by identifying loci that potentially influence nephrogenesis, podocyte function, angiogenesis, solute transport and metabolic functions of the kidney.
Metadata last modified: 19 Dec 2024 11:38
Altmetric