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A genome-wide association study of alcohol dependence

Bierut, Laura J. ; Agrawal, Arpana ; Bucholz, Kathleen K. ; Doheny, Kimberly F. ; Laurie, Cathy ; Pugh, Elizabeth ; Fisher, Sherri ; Fox, Louis ; Howells, William ; Bertelsen, Sarah ; Hinrichs, Anthony L. ; Almasy, Laura ; Breslau, Naomi ; Culverhouse, Robert C. ; Dick, Danielle M. ; Edenberg, Howard J. ; Foroud, Tatiana ; Grucza, Richard A. ; Hatsukami, Dorothy ; Hesselbrock, Victor ; Johnson, Eric O. ; Kramer, John ; Krueger, Robert F. ; Kuperman, Samuel ; Lynskey, Michael ; Mann, Karl ; Neuman, Rosalind J. ; Nöthen, Markus M. ; Nurnberger, John I. ; Porjesz, Bernice ; Ridinger, Monika ; Saccone, Nancy L. ; Saccone, Scott F. ; Schuckit, Marc A. ; Tischfield, Jay A. ; Wang, Jen C. ; Rietschel, Marcella ; Goate, Alison M. ; Rice, John P.



Abstract

Excessive alcohol consumption is one of the leading causes of preventable death in the United States. Approximately 14% of those who use alcohol meet criteria during their lifetime for alcohol dependence, which is characterized by tolerance, withdrawal, inability to stop drinking, and continued drinking despite serious psychological or physiological problems. We explored genetic influences on ...

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