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Increased Renin Production in Mice With Deletion of Peroxisome Proliferator-Activated Receptor-γ in Juxtaglomerular Cells

Desch, Michael ; Schreiber, Andrea ; Schweda, Frank ; Madsen, Kirsten ; Friis, Ulla G. ; Weatherford, Eric T. ; Sigmund, Curt D. ; Sequeira Lopez, Maria Luisa ; Gomez, R. Ariel ; Todorov, Vladimir T.



Zusammenfassung

We recently found that endogenous (free fatty acids) and pharmacological (thiazolidinediones) agonists of nuclear receptor Peroxisome proliferator-activated receptor (PPAR)gamma stimulate renin transcription. In addition, the renin gene was identified as a direct target of PPAR gamma. The mouse renin gene is regulated by PPAR gamma through a distal enhancer direct repeat closely related to ...

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