Zusammenfassung
Circadian rhythm refers to the periodic 24-h cycle that underlies many biological processes. In rheumatic disease, e.g., rheumatoid arthritis, circadian ups and downs of cytokine levels strongly correlate with daily fluctuations of symptoms, like morning stiffness or pain. This review gives a short overview regarding circadian rhythms in general and in the context of rheumatic disease, like ...
Zusammenfassung
Circadian rhythm refers to the periodic 24-h cycle that underlies many biological processes. In rheumatic disease, e.g., rheumatoid arthritis, circadian ups and downs of cytokine levels strongly correlate with daily fluctuations of symptoms, like morning stiffness or pain. This review gives a short overview regarding circadian rhythms in general and in the context of rheumatic disease, like rheumatoid arthritis. The hypothesis is introduced that clinical efficacy of anti-inflammatory treatment for rheumatoid arthritis is dependent on the time of the day when the medication is used. Clinical implications of this hypothesis are discussed in detail. In summary, it is shown that the anti-inflammatory potential is increased when anti-inflammatory drugs, like glucocorticoids, are released about 2.00 in the morning and not the evening before.
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