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Synovial fibroblasts spread rheumatoid arthritis to unaffected joints

Lefèvre, Stephanie ; Knedla, Anette ; Tennie, Christoph ; Kampmann, Andreas ; Wunrau, Christina ; Dinser, Robert ; Korb, Adelheid ; Schnäker, Eva-Maria ; Tarner, Ingo H ; Robbins, Paul D ; Evans, Christopher H ; Stürz, Henning ; Steinmeyer, Jürgen ; Gay, Steffen ; Schölmerich, Jürgen ; Pap, Thomas ; Müller-Ladner, Ulf ; Neumann, Elena



Zusammenfassung

Active rheumatoid arthritis originates from few joints but subsequently affects the majority of joints. Thus far, the pathways of the progression of the disease are largely unknown. As rheumatoid arthritis synovial fibroblasts (RASFs) which can be found in RA synovium are key players in joint destruction and are able to migrate in vitro, we evaluated the potential of RASFs to spread the disease ...

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