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A Genome-Wide Association Study Reveals Variants in ARL15 that Influence Adiponectin Levels

Abecasis, Gonçalo R. ; Richards, J. Brent ; Waterworth, Dawn ; O'Rahilly, Stephen ; Hivert, Marie-France ; Loos, Ruth J. F. ; Perry, John R. B. ; Tanaka, Toshiko ; Timpson, Nicholas John ; Semple, Robert K. ; Soranzo, Nicole ; Song, Kijoung ; Rocha, Nuno ; Grundberg, Elin ; Dupuis, Josée ; Florez, Jose C. ; Langenberg, Claudia ; Prokopenko, Inga ; Saxena, Richa ; Sladek, Robert ; Aulchenko, Yurii ; Evans, David ; Waeber, Gerard ; Erdmann, Jeanette ; Burnett, Mary-Susan ; Sattar, Naveed ; Devaney, Joseph ; Willenborg, Christina ; Hingorani, Aroon ; Witteman, Jaquelin C. M. ; Vollenweider, Peter ; Glaser, Beate ; Hengstenberg, Christian ; Ferrucci, Luigi ; Melzer, David ; Stark, Klaus ; Deanfield, John ; Winogradow, Janina ; Grassl, Martina ; Hall, Alistair S. ; Egan, Josephine M. ; Thompson, John R. ; Ricketts, Sally L. ; König, Inke R. ; Reinhard, Wibke ; Grundy, Scott ; Wichmann, H-Erich ; Barter, Phil ; Mahley, Robert ; Kesaniemi, Y. Antero ; Rader, Daniel J. ; Reilly, Muredach P. ; Epstein, Stephen E. ; Stewart, Alexandre F. R. ; Van Duijn, Cornelia M. ; Schunkert, Heribert ; Burling, Keith ; Deloukas, Panos ; Pastinen, Tomi ; Samani, Nilesh J. ; McPherson, Ruth ; Davey Smith, George ; Frayling, Timothy M. ; Wareham, Nicholas J. ; Meigs, James B. ; Mooser, Vincent ; Spector, Tim D.



Zusammenfassung

The adipocyte-derived protein adiponectin is highly heritable and inversely associated with risk of type 2 diabetes mellitus (T2D) and coronary heart disease (CHD). We meta-analyzed 3 genome-wide association studies for circulating adiponectin levels (n = 8,531) and sought validation of the lead single nucleotide polymorphisms ( SNPs) in 5 additional cohorts (n = 6,202). Five SNPs were ...

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