Weber, Markus ; Sporrer, Daniela ; Weigert, Johanna ; Wanninger, Josef ; Neumeier, Markus ; Wurm, Sylvia ; Stögbauer, Fabian ; Kopp, Andrea ; Bala, Margarita ; Schäffler, Andreas ; Buechler, Christa
Alternative Links zum Volltext:DOIVerlag
| Dokumentenart: | Artikel |
|---|
| Titel eines Journals oder einer Zeitschrift: | FEBS Letters |
|---|
| Verlag: | ELSEVIER SCIENCE BV |
|---|
| Ort der Veröffentlichung: | AMSTERDAM |
|---|
| Band: | 583 |
|---|
| Nummer des Zeitschriftenheftes oder des Kapitels: | 22 |
|---|
| Seitenbereich: | S. 3718-3724 |
|---|
| Datum: | 2009 |
|---|
| Institutionen: | Medizin > Lehrstuhl für Innere Medizin I |
|---|
| Identifikationsnummer: | | Wert | Typ |
|---|
| 10.1016/j.febslet.2009.10.008 | DOI |
|
|---|
| Stichwörter / Keywords: | INSULIN-RESISTANCE; METABOLIC SYNDROME; IL-6 PRODUCTION; PROTEIN-KINASE; DEFICIENT MICE; INFLAMMATION; MACROPHAGES; ACTIVATION; RECEPTOR; PATHWAY; Type 2 diabetes mellitus; Obesity; Adiponectin; Galectin-3; Monocyte |
|---|
| Dewey-Dezimal-Klassifikation: | 600 Technik, Medizin, angewandte Wissenschaften > 610 Medizin |
|---|
| Status: | Veröffentlicht |
|---|
| Begutachtet: | Ja, diese Version wurde begutachtet |
|---|
| An der Universität Regensburg entstanden: | Ja |
|---|
| Dokumenten-ID: | 66764 |
|---|
Web of Science
Zusammenfassung
Galectin-3 plays a role in atherosclerotic diseases, and the effect of adiponectin that protects from atherosclerotic diseases on monocytic galectin-3 was analysed. Adiponectin reduced galectin-3 mRNA, its cellular and soluble form, and this effect was impaired in T2D cells. Cellular galectin-3 was higher in monocytes of overweight than normal-weight donors and was highest in T2D cells. Cellular ...
Zusammenfassung
Galectin-3 plays a role in atherosclerotic diseases, and the effect of adiponectin that protects from atherosclerotic diseases on monocytic galectin-3 was analysed. Adiponectin reduced galectin-3 mRNA, its cellular and soluble form, and this effect was impaired in T2D cells. Cellular galectin-3 was higher in monocytes of overweight than normal-weight donors and was highest in T2D cells. Cellular galectin-3 positively correlated with the BMI of the donors and negatively with soluble monocyte galectin-3. Circulating levels of total adiponectin did not correlate with cellular or soluble galectin-3 indicating that additional factors contribute to higher cellular monocytic galectin-3 in obesity and T2D. (C) 2009 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.
Altmetric