| Dokumentenart: | Artikel | ||||
|---|---|---|---|---|---|
| Titel eines Journals oder einer Zeitschrift: | American Journal of Physiology-Renal Physiology | ||||
| Verlag: | AMER PHYSIOLOGICAL SOC | ||||
| Ort der Veröffentlichung: | BETHESDA | ||||
| Band: | 297 | ||||
| Nummer des Zeitschriftenheftes oder des Kapitels: | 5 | ||||
| Seitenbereich: | F1371-F1380 | ||||
| Datum: | 2009 | ||||
| Institutionen: | Biologie und Vorklinische Medizin > Institut für Physiologie > Prof. Dr. Armin Kurtz | ||||
| Identifikationsnummer: |
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| Stichwörter / Keywords: | RECEPTOR NULL MICE; BLOOD-PRESSURE; DEFICIENT MICE; JUXTAGLOMERULAR CELLS; CONVERTING ENZYME; GENE-EXPRESSION; MUTANT MICE; KIDNEY; LACKING; 1A; development; angiotensin II | ||||
| Dewey-Dezimal-Klassifikation: | 500 Naturwissenschaften und Mathematik > 570 Biowissenschaften, Biologie | ||||
| Status: | Veröffentlicht | ||||
| Begutachtet: | Ja, diese Version wurde begutachtet | ||||
| An der Universität Regensburg entstanden: | Ja | ||||
| Dokumenten-ID: | 66777 |
Web of ScienceZusammenfassung
Machura K, Steppan D, Neubauer B, Alenina N, Coffman TM, Facemire CS, Hilgers KF, Eckardt K, Wagner C, Kurtz A. Developmental renin expression in mice with a defective renin-angiotensin system. Am J Physiol Renal Physiol 297: F1371-F1380, 2009. First published August 26, 2009; doi: 10.1152/ajprenal.00378.2009.-During nephrogenesis, renin expression shifts from the vessel walls of interlobular ...
Zusammenfassung
Machura K, Steppan D, Neubauer B, Alenina N, Coffman TM, Facemire CS, Hilgers KF, Eckardt K, Wagner C, Kurtz A. Developmental renin expression in mice with a defective renin-angiotensin system. Am J Physiol Renal Physiol 297: F1371-F1380, 2009. First published August 26, 2009; doi: 10.1152/ajprenal.00378.2009.-During nephrogenesis, renin expression shifts from the vessel walls of interlobular arteries to the terminal portions of afferent arterioles in a wavelike pattern. Since the mechanisms responsible for the developmental deactivation of renin expression are as yet unknown, we hypothesized that the developing renin-angiotensin system (RAS) may downregulate itself via negative feedback to prevent overactivity of renin. To test for a possible role of angiotensin II in the developmental deactivation of renin expression, we studied the development of intrarenal renin expression in mice lacking ANG II AT(1a), AT(1b), or AT(2) receptors and in animals with abolished circulating ANG II due to deletion of the gene for angiotensin I-converting enzyme (ACE). The development of intrarenal renin expression was normal in mice lacking ANG II AT(1b) or AT(2) receptors. In animals lacking both ANG II AT(1a) and AT(1b) receptors, ACE, or ANG II AT(1a) receptors, renin expression was normal early and renin disappeared from mature vessels until development of cortical interlobular and afferent arterioles began. The development of cortical vessels in these genotypes was accompanied by a markedly increased number of renin-expressing cells, many of which were ectopically located and attached in a grapelike fashion to the outer vessel perimeter. Although the number of renin-expressing cells declined during final maturation of the kidneys, the atypical distribution pattern of renin cells was maintained. These findings suggest that ANG II does not play a central role in the typical developmental shift in renin expression from the arcuate vessels to the afferent arterioles. During postnatal maturation of mouse kidneys, interruption of the RAS causes severe hyperplasia of renin cells via a mechanism that centrally involves AT(1a) receptors. However, the distribution pattern of renin cells in adult kidneys with an interrupted RAS does not mimic any normal developmental stage since renin expression is frequently found in cells outside the arteriolar vessel walls in RAS mutants.
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