Stefanova, Nadia ; Hainzer, Monika ; Stemberger, Sylvia ; Couillard-Després, Sebastien 
; Aigner, Ludwig ; Poewe, Werner ; Wenning, Gregor K.
Alternative Links zum Volltext:DOIVerlag
| Dokumentenart: | Artikel |
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| Titel eines Journals oder einer Zeitschrift: | Experimental Neurology |
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| Verlag: | ACADEMIC PRESS INC ELSEVIER SCIENCE |
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| Ort der Veröffentlichung: | SAN DIEGO |
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| Band: | 219 |
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| Nummer des Zeitschriftenheftes oder des Kapitels: | 1 |
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| Seitenbereich: | S. 368-371 |
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| Datum: | 2009 |
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| Institutionen: | Medizin > Lehrstuhl für Neurologie |
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| Identifikationsnummer: | | Wert | Typ |
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| 10.1016/j.expneurol.2009.05.016 | DOI |
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| Stichwörter / Keywords: | PARKINSONS-DISEASE; NEURONS; PATHOLOGY; PATIENT; Multiple system atrophy; Striatonigral degeneration; alpha-synuclein; Glial cytoplasmic inclusions; Transgenic mouse; Striatal transplantation |
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| Dewey-Dezimal-Klassifikation: | 600 Technik, Medizin, angewandte Wissenschaften > 610 Medizin |
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| Status: | Veröffentlicht |
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| Begutachtet: | Ja, diese Version wurde begutachtet |
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| An der Universität Regensburg entstanden: | Ja |
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| Dokumenten-ID: | 66946 |
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Web of Science
Zusammenfassung
Multiple system atrophy (MSA), a fatal neurodegenerative disorder, is the second most common cause of parkinsonism and frequently associated with autonomic failure. Previous work from our laboratory has shown that striatal grafts survive and exert functional effects in toxin-induced rodent models of MSA-P, the parkinson variant characterized by levodopa resistance due to loss of striatal ...
Zusammenfassung
Multiple system atrophy (MSA), a fatal neurodegenerative disorder, is the second most common cause of parkinsonism and frequently associated with autonomic failure. Previous work from our laboratory has shown that striatal grafts survive and exert functional effects in toxin-induced rodent models of MSA-P, the parkinson variant characterized by levodopa resistance due to loss of striatal medium-sized spiny neurons. It is unknown whether oligodendroglial alpha-synuclein signature lesions affect graft survival in MSA. Recent reports on neurotransplantation in Parkinson's disease patients suggest a possible host-to-graft disease propagation of alpha-synuclein pathology which may be relevant to transplantation in MSA as well. We here demonstrate that embryonic E14 striatal allografts show reduced p-zone volume and dopaminergic graft reinnervation accompanied by increased gliosis in a transgenic MSA mouse model featuring alpha-synuclein oligodendrogliopathy. Oligodendrocytes expressing host-specific alpha-synuclein migrate into the graft tissue after 3 months of survival. Our data suggest that the presence of MSA-like alpha-synuclein oligodendrogliopathy and related to it pro-inflammatory microenvironment may compromise the connectivity and neurorestorative outcome of striatal grafts. (C) 2009 Elsevier Inc. All rights reserved.
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