Riquelme, Paloma ; Gövert, Felix ; Geissler, Edward K. ; Fändrich, Fred ; Hutchinson, James A. 
Alternative Links zum Volltext:DOIVerlag
| Dokumentenart: | Artikel |
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| Titel eines Journals oder einer Zeitschrift: | Transplant Immunology |
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| Verlag: | ELSEVIER SCIENCE BV |
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| Ort der Veröffentlichung: | AMSTERDAM |
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| Band: | 21 |
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| Nummer des Zeitschriftenheftes oder des Kapitels: | 3 |
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| Seitenbereich: | S. 162-165 |
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| Datum: | 2009 |
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| Institutionen: | Medizin > Lehrstuhl für Chirurgie |
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| Identifikationsnummer: | | Wert | Typ |
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| 10.1016/j.trim.2009.03.004 | DOI |
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| Stichwörter / Keywords: | RENAL-TRANSPLANTATION; STEM-CELLS; MACROPHAGES; INDUCTION; TOLERANCE; THERAPY; LONG; Macrophage; TAIC; Cell-based immunotherapy |
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| Dewey-Dezimal-Klassifikation: | 600 Technik, Medizin, angewandte Wissenschaften > 610 Medizin |
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| Status: | Veröffentlicht |
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| Begutachtet: | Ja, diese Version wurde begutachtet |
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| An der Universität Regensburg entstanden: | Ja |
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| Dokumenten-ID: | 67093 |
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Web of Science
Zusammenfassung
The Transplant Acceptance-inducing Cell (TAIC) is a form of immunoregulatory macrophage which appears to be capable of establishing a state of alloantigen-specific partial tolerance of solid organ transplants in renal transplant recipients. This report establishes that human TAICs do not elicit a proliferative response from co-cultured allogeneic T cells. More significantly, it has been shown ...
Zusammenfassung
The Transplant Acceptance-inducing Cell (TAIC) is a form of immunoregulatory macrophage which appears to be capable of establishing a state of alloantigen-specific partial tolerance of solid organ transplants in renal transplant recipients. This report establishes that human TAICs do not elicit a proliferative response from co-cultured allogeneic T cells. More significantly, it has been shown that TAICs are able to suppress proliferation of allogeneic CD4(+) and CD8(+) T cells after mitogenic stimulation. This suppressive activity can be attributed to the deletion of activated T cells by TAICs and to the secretion of a soluble inhibitor of T cell proliferation. It is further shown that the acquisition of T cell-suppressive properties by human TAICs depends upon an unidentified component of human serum. (C) 2009 Elsevier B.V. All rights reserved.
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