; Männistö, Satu
; Spiegelman, Donna ; Hunter, David J. ; Bernstein, Leslie ; van den Brandt, Piet A.
; Buring, Julie E. ; Cho, Eunyoung ; English, Dallas R.
; Flood, Andrew ; Freudenheim, Jo L. ; Giles, Graham G.
; Giovannucci, Edward ; Håkansson, Niclas
; Horn-Ross, Pamela L. ; Jacobs, Eric J. ; Leitzmann, Michael F. ; Marshall, James R. ; McCullough, Marjorie L. ; Miller, Anthony B. ; Rohan, Thomas E. ; Ross, Julie A. ; Schatzkin, Arthur ; Schouten, Leo J. ; Virtamo, Jarmo ; Wolk, Alicja ; Zhang, Shumin M. ; Smith-Warner, Stephanie A. | Item type: | Article | ||||
|---|---|---|---|---|---|
| Journal or Publication Title: | Cancer Epidemiology, Biomarkers & Prevention | ||||
| Publisher: | AMER ASSOC CANCER RESEARCH | ||||
| Place of Publication: | PHILADELPHIA | ||||
| Volume: | 18 | ||||
| Number of Issue or Book Chapter: | 6 | ||||
| Page Range: | pp. 1730-1739 | ||||
| Date: | 2009 | ||||
| Institutions: | Medicine > Institut für Epidemiologie und Präventivmedizin | ||||
| Identification Number: |
| ||||
| Keywords: | FOOD-FREQUENCY QUESTIONNAIRE; COLORECTAL-CANCER; UNITED-STATES; CALIFORNIA TEACHERS; DIETARY CAROTENOIDS; PROSPECTIVE COHORT; KIDNEY CANCER; MALE SMOKERS; FOLLOW-UP; CARCINOMA; | ||||
| Dewey Decimal Classification: | 600 Technology > 610 Medical sciences Medicine | ||||
| Status: | Published | ||||
| Refereed: | Yes, this version has been refereed | ||||
| Created at the University of Regensburg: | Yes | ||||
| Item ID: | 67111 |
Abstract
Fruit and vegetable consumption has been hypothesized to reduce the risk of renal cell cancer. We conducted a pooled analysis of 13 prospective studies, including 1,478 incident cases of renal cell cancer (709 women and 769 men) among 530,469 women and 244,483 men followed for up to 7 to 20 years. Participants completed a validated food-frequency questionnaire at baseline. Using the primary data ...

Abstract
Fruit and vegetable consumption has been hypothesized to reduce the risk of renal cell cancer. We conducted a pooled analysis of 13 prospective studies, including 1,478 incident cases of renal cell cancer (709 women and 769 men) among 530,469 women and 244,483 men followed for up to 7 to 20 years. Participants completed a validated food-frequency questionnaire at baseline. Using the primary data from each study, the study-specific relative risks (RR) were calculated using the Cox proportional hazards model and then pooled using a random effects model. We found that fruit and vegetable consumption was associated with a reduced risk of renal cell cancer. Compared with <200 g/d of fruit and vegetable intake, the pooled multivariate RR for >= 600 g/d was 0.68 [95% confidence interval (95% CI) = 0.54-0.87; P for between-studies heterogeneity = 0.86; P for trend = 0.001]. Compared with <100 g/d, the pooled multivariate RRs (95% CI) for 400 g/d were 0.79 (0.63-0.99; P for trend = 0.03) for total fruit and 0.72 (0.48-1.08; P for trend = 0.07) for total vegetables. For specific carotenoids, the pooled multivariate RRs (95% CIs) comparing the highest and lowest quintiles were 0.87 (0.73-1.03) for alpha-carotene, 0.82 (0.69-0.98) for beta-carotene, 0.86 (0.73-1.01) for beta-cryptoxanthin, 0.82 (0.64-1.06) for lutein/zeaxanthin, and 1.13 (0.95-1.34) for lycopene. In conclusion, increasing fruit and vegetable consumption is associated with decreasing risk of renal cell cancer; carotenoids present in fruit and vegetables may partly contribute to this protection. (Cancer Epidemiol Biomarkers Prev 2009;18(6):1730-9)
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