; Lindgren, Cecilia M. ; Heid, Iris M. ; Randall, Joshua C. ; Lamina, Claudia
; Steinthorsdottir, Valgerdur ; Qi, Lu ; Speliotes, Elizabeth K. ; Thorleifsson, Gudmar
; Willer, Cristen J. ; Herrera, Blanca M. ; Jackson, Anne U. ; Lim, Noha ; Scheet, Paul
; Soranzo, Nicole
; Amin, Najaf
; Aulchenko, Yurii S. ; Chambers, John C. ; Drong, Alexander ; Luan, Jian'an ; Lyon, Helen N.
; Rivadeneira, Fernando ; Sanna, Serena
; Timpson, Nicholas J. ; Zillikens, M. Carola ; Zhao, Jing Hua ; Almgren, Peter ; Bandinelli, Stefania ; Bennett, Amanda J. ; Bergman, Richard N. ; Bonnycastle, Lori L. ; Bumpstead, Suzannah J. ; Chanock, Stephen J. ; Cherkas, Lynn ; Chines, Peter
; Coin, Lachlan
; Cooper, Cyrus ; Crawford, Gabriel ; Doering, Angela ; Dominiczak, Anna
; Doney, Alex S. F. ; Ebrahim, Shah
; Elliott, Paul ; Erdos, Michael R. ; Estrada, Karol ; Ferrucci, Luigi ; Fischer, Guido
; Forouhi, Nita G.
; Gieger, Christian ; Grallert, Harald ; Groves, Christopher J. ; Grundy, Scott ; Guiducci, Candace ; Hadley, David ; Hamsten, Anders ; Havulinna, Aki S. ; Hofman, Albert
; Holle, Rolf
; Holloway, John W. ; Illig, Thomas ; Isomaa, Bo ; Jacobs, Leonie C. ; Jameson, Karen ; Jousilahti, Pekka
; Karpe, Fredrik ; Kuusisto, Johanna ; Laitinen, Jaana ; Lathrop, G. Mark
; Lawlor, Debbie A. ; Mangino, Massimo ; McArdle, Wendy L.
; Meitinger, Thomas ; Morken, Mario A. ; Morris, Andrew P. ; Munroe, Patricia ; Narisu, Narisu
; Nordström, Anna ; Nordström, Peter ; Oostra, Ben A.
; Palmer, Colin N. A.
; Payne, Felicity ; Peden, John F.
; Prokopenko, Inga ; Renström, Frida ; Ruokonen, Aimo ; Salomaa, Veikko ; Sandhu, Manjinder S. ; Scott, Laura J. ; Scuteri, Angelo ; Silander, Kaisa ; Song, Kijoung ; Yuan, Xin ; Stringham, Heather M. ; Swift, Amy J.
; Tuomi, Tiinamaija ; Uda, Manuela ; Vollenweider, Peter ; Waeber, Gerard
; Wallace, Chris
; Walters, G. Bragi
; Weedon, Michael N. ; Witteman, Jacqueline C. M.
; Zhang, Cuilin
; Zhang, Weihua
; Caulfield, Mark J. ; Collins, Francis S. ; Davey Smith, George ; Day, Ian N. M. ; Franks, Paul W. ; Hattersley, Andrew T. ; Hu, Frank B.
; Jarvelin, Marjo-Riitta ; Kong, Augustine ; Kooner, Jaspal S. ; Laakso, Markku ; Lakatta, Edward ; Mooser, Vincent ; Morris, Andrew D. ; Peltonen, Leena ; Samani, Nilesh J. ; Spector, Timothy D. ; Strachan, David P. ; Tanaka, Toshiko ; Tuomilehto, Jaakko ; Uitterlinden, André G. ; van Duijn, Cornelia M. ; Wareham, Nicholas J.
; Watkins for the PROCARDIS consortia, Hugh ; Waterworth, Dawn M. ; Boehnke, Michael
; Deloukas, Panos ; Groop, Leif ; Hunter, David J. ; Thorsteinsdottir, Unnur ; Schlessinger, David ; Wichmann, H.-Erich ; Frayling, Timothy M.
; Abecasis, Gonçalo R. ; Hirschhorn, Joel N.
; Loos, Ruth J. F. ; Stefansson, Kari ; Mohlke, Karen L.
; Barroso, Inês ; McCarthy for the GIANT consortium, Mark I. | Item type: | Article | ||||
|---|---|---|---|---|---|
| Journal or Publication Title: | PLoS Genetics | ||||
| Publisher: | PUBLIC LIBRARY SCIENCE | ||||
| Place of Publication: | SAN FRANCISCO | ||||
| Volume: | 5 | ||||
| Number of Issue or Book Chapter: | 6 | ||||
| Page Range: | e1000508 | ||||
| Date: | 2009 | ||||
| Institutions: | Medicine > Institut für Epidemiologie und Präventivmedizin | ||||
| Identification Number: |
| ||||
| Keywords: | FTO GENE; WAIST CIRCUMFERENCE; ADULT OBESITY; ENVIRONMENTAL-CONDITIONS; INSULIN-RESISTANCE; SEQUENCE VARIANTS; COMMON VARIANTS; EXPRESSION; IMPUTATION; HEIGHT; | ||||
| Dewey Decimal Classification: | 600 Technology > 610 Medical sciences Medicine | ||||
| Status: | Published | ||||
| Refereed: | Yes, this version has been refereed | ||||
| Created at the University of Regensburg: | Yes | ||||
| Item ID: | 67156 |
Abstract
To identify genetic loci influencing central obesity and fat distribution, we performed a meta-analysis of 16 genome-wide association studies (GWAS, N = 38,580) informative for adult waist circumference (WC) and waist-hip ratio (WHR). We selected 26 SNPs for follow-up, for which the evidence of association with measures of central adiposity (WC and/or WHR) was strong and disproportionate to that ...

Abstract
To identify genetic loci influencing central obesity and fat distribution, we performed a meta-analysis of 16 genome-wide association studies (GWAS, N = 38,580) informative for adult waist circumference (WC) and waist-hip ratio (WHR). We selected 26 SNPs for follow-up, for which the evidence of association with measures of central adiposity (WC and/or WHR) was strong and disproportionate to that for overall adiposity or height. Follow-up studies in a maximum of 70,689 individuals identified two loci strongly associated with measures of central adiposity; these map near TFAP2B (WC, P = 1.9x10(-11)) and MSRA (WC, P = 8.9x10(-9)). A third locus, near LYPLAL1, was associated with WHR in women only (P = 2.6x10(-8)). The variants near TFAP2B appear to influence central adiposity through an effect on overall obesity/fat-mass, whereas LYPLAL1 displays a strong female-only association with fat distribution. By focusing on anthropometric measures of central obesity and fat distribution, we have identified three loci implicated in the regulation of human adiposity.
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