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Lymphotoxin β receptor signaling promotes tertiary lymphoid organogenesis in the aorta adventitia of aged ApoE−/− mice

Gräbner, Rolf ; Lötzer, Katharina ; Döpping, Sandra ; Hildner, Markus ; Radke, Dörte ; Beer, Michael ; Spanbroek, Rainer ; Lippert, Beatrix ; Reardon, Catherine A. ; Getz, Godfrey S. ; Fu, Yang-Xin ; Hehlgans, Thomas ; Mebius, Reina E. ; van der Wall, Michael ; Kruspe, Dagmar ; Englert, Christoph ; Lovas, Agnes ; Hu, Desheng ; Randolph, Gwendalyn J. ; Weih, Falk ; Habenicht, Andreas J.R.



Zusammenfassung

Atherosclerosis involves a macrophage-rich inflammation in the aortic intima. It is increasingly recognized that this intimal inflammation is paralleled over time by a distinct inflammatory reaction in adjacent adventitia. Though cross talk between the coordinated inflammatory foci in the intima and the adventitia seems implicit, the mechanism(s) underlying their communication is unclear. Here, ...

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