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Joint analysis of individual participants’ data from 17 studies on the association of theIL6variant -174G>C with circulating glucose levels, interleukin-6 levels, and body mass index

Huth, Cornelia ; Illig, Thomas ; Herder, Christian ; Gieger, Christian ; Grallert, Harald ; Vollmert, Caren ; Rathmann, Wolfgang ; Hamid, Yasmin H. ; Pedersen, Oluf ; Hansen, Torben ; Thorand, Barbara ; Meisinger, Christa ; Döring, Angela ; Klopp, Norman ; Gohlke, Henning ; Lieb, Wolfgang ; Hengstenberg, Christian ; Lyssenko, Valeriya ; Groop, Leif ; Ireland, Helen ; Stephens, Jeffrey W. ; Wernstedt Asterholm, Ingrid ; Jansson, John-Olov ; Boeing, Heiner ; Möhlig, Matthias ; Stringham, Heather M. ; Boehnke, Michael ; Tuomilehto, Jaakko ; Fernandez-Real, Jose-Manuel ; Lopez-Bermejo, Abel ; Gallart, Luis ; Vendrell, Joan ; Humphries, Steve E. ; Kronenberg, Florian ; Wichmann, H.-Erich ; Heid, Iris M.



Zusammenfassung

Background. Several studies have investigated associations between the -174GC single nucleotide polymorphism (rs1800795) of the IL6 gene and phenotypes related to type 2 diabetes mellitus (T2DM) but presented inconsistent results. Aims. This joint analysis aimed to clarify whether IL6 -174GC was associated with glucose and circulating interleukin-6 concentrations as well as body mass index (BMI). ...

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