Zeitz, O ; Berna-Thill, M ; Bartsch, U ; Strauß, O ; Richard, G
Alternative Links zum Volltext:DOIVerlag
| Dokumentenart: | Artikel |
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| Titel eines Journals oder einer Zeitschrift: | Klinische Monatsblätter für Augenheilkunde |
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| Verlag: | GEORG THIEME VERLAG KG |
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| Ort der Veröffentlichung: | STUTTGART |
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| Band: | 226 |
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| Nummer des Zeitschriftenheftes oder des Kapitels: | 01 |
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| Seitenbereich: | S. 27-30 |
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| Datum: | 2009 |
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| Institutionen: | Medizin > Lehrstuhl für Augenheilkunde |
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| Identifikationsnummer: | | Wert | Typ |
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| 10.1055/s-2008-1027600 | DOI |
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| Stichwörter / Keywords: | FACTOR-H POLYMORPHISM; HUMAN RPE CELLS; MACULAR DEGENERATION; DIABETIC-RETINOPATHY; VITAMIN-C; ERYTHROPOIETIN; LIPOFUSCIN; VEGF; APOPTOSIS; DAMAGE; Retina; Pharmacology; Pathology |
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| Dewey-Dezimal-Klassifikation: | 600 Technik, Medizin, angewandte Wissenschaften > 610 Medizin |
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| Status: | Veröffentlicht |
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| Begutachtet: | Ja, diese Version wurde begutachtet |
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| An der Universität Regensburg entstanden: | Ja |
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| Dokumenten-ID: | 67593 |
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Web of Science
Zusammenfassung
Oxidative stress at the retinal pigment epithelium (RPE) is involved in the pathophysiology of age-related macula degeneration (ARMD). Observations on a clinical or laboratory level have revealed that supplementation of antioxidative scavengers failed in many cases. A potential therapeutic target is the cellular signal transduction cascade initiated by oxidative stress which results, e.g., in ...
Zusammenfassung
Oxidative stress at the retinal pigment epithelium (RPE) is involved in the pathophysiology of age-related macula degeneration (ARMD). Observations on a clinical or laboratory level have revealed that supplementation of antioxidative scavengers failed in many cases. A potential therapeutic target is the cellular signal transduction cascade initiated by oxidative stress which results, e.g., in altered expression of pro- and antiagiogenic factors as well as induction of apoptosis. This review summarises the current literature on cellular effects of free radicals and deduces potential therapeutic approaches to protect the RPE from oxidative damage.
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