Schütze, Stefan ; Tchikov, Vladimir ; Schneider-Brachert, Wulf
Alternative Links zum Volltext:DOIVerlag
| Dokumentenart: | Artikel |
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| Titel eines Journals oder einer Zeitschrift: | Nature Reviews Molecular Cell Biology |
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| Verlag: | NATURE PUBLISHING GROUP |
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| Ort der Veröffentlichung: | LONDON |
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| Band: | 9 |
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| Nummer des Zeitschriftenheftes oder des Kapitels: | 8 |
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| Seitenbereich: | S. 655-662 |
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| Datum: | 2008 |
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| Institutionen: | Medizin > Lehrstuhl für Medizinische Mikrobiologie und Hygiene |
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| Identifikationsnummer: | | Wert | Typ |
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| 10.1038/nrm2430 | DOI |
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| Stichwörter / Keywords: | TUMOR-NECROSIS-FACTOR; NF-KAPPA-B; SPHINGOMYELINASE-DERIVED CERAMIDE; ACTIVATED PROTEIN-KINASES; FACTOR-INDUCED APOPTOSIS; INDUCED CELL-DEATH; ACID SPHINGOMYELINASE; NEUTRAL SPHINGOMYELINASE; MEDIATED ENDOCYTOSIS; GENE-EXPRESSION; |
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| Dewey-Dezimal-Klassifikation: | 600 Technik, Medizin, angewandte Wissenschaften > 610 Medizin |
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| Status: | Veröffentlicht |
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| Begutachtet: | Ja, diese Version wurde begutachtet |
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| An der Universität Regensburg entstanden: | Ja |
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| Dokumenten-ID: | 67964 |
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Web of Science
Zusammenfassung
The death receptors tumour-necrosis factor receptor-1 (TNFR1) and CD95 (also known as FAS and APO-1) transduce signals that promote cell death by apoptosis. However, these receptors are also capable of inducing anti-apoptotic signals through the activation of the transcription factor nuclear factor-kappa B (NF-kappa B) or through activation of the proliferative mitogen-activated protein kinase ...
Zusammenfassung
The death receptors tumour-necrosis factor receptor-1 (TNFR1) and CD95 (also known as FAS and APO-1) transduce signals that promote cell death by apoptosis. However, these receptors are also capable of inducing anti-apoptotic signals through the activation of the transcription factor nuclear factor-kappa B (NF-kappa B) or through activation of the proliferative mitogen-activated protein kinase (MAPK) cascade. Recent findings reveal a role for receptor internalization and endosomal trafficking in selectively transmitting the signals that lead either to apoptosis or to the survival of the cell.
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