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EV01: A phase I trial in healthy HIV negative volunteers to evaluate a clade C HIV vaccine, NYVAC-C undertaken by the EuroVacc Consortium

Bart, Pierre-Alexandre ; Goodall, Ruth ; Barber, Tristan ; Harari, Alexandre ; Guimaraes-Walker, Ana ; Khonkarly, Mona ; Sheppard, Neil C. ; Bangala, Yolanda ; Frachette, Marie-Joelle ; Wagner, Ralf ; Liljeström, Peter ; Kraehenbuhl, Jean-Pierre ; Girard, Marc ; Goudsmit, Jaap ; Esteban, Mariano ; Heeney, Jonathan ; Sattentau, Quentin ; McCormack, Sheena ; Babiker, Abdel ; Pantaleo, Giuseppe ; Weber, Jonathan



Zusammenfassung

NYVAC-C (vP2010), a recombinant vector expressing HIV subtype C gag, pot, env and nef antigens, was tested in a phase I study in healthy, HIV negative volunteers in London and Lausanne. Twenty-four participants were randomised to receive NYVAC-C (20) or matching placebo (4) at weeks 0 and 4, and assessed for safety and immunogenicity over 48 weeks. There were no serious adverse events, and no ...

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