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Extracellular SH3 Domain Containing Proteins – Features of a New Protein Family

Stoll, R. ; Bosserhoff, A.



Zusammenfassung

In the year 1994, the protein MIA (melanoma inhibitory activity) was found to be strongly expressed and secreted by malignant melanomas and subsequent studies revealed that MIA has an important function in melanoma development and invasion. Multidimensional NMR- spectroscopy and x- ray crystallography revealed that recombinant human MIA adopts a Src homology 3 (SH3) domain- like fold in solution, ...

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