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Repeated Replication and a Prospective Meta-Analysis of the Association Between Chromosome 9p21.3 and Coronary Artery Disease

Schunkert, Heribert ; Götz, Anika ; Braund, Peter ; McGinnis, Ralph ; Tregouet, David-Alexandre ; Mangino, Massimo ; Linsel-Nitschke, Patrick ; Cambien, Francois ; Hengstenberg, Christian ; Stark, Klaus ; Blankenberg, Stefan ; Tiret, Laurence ; Ducimetiere, Pierre ; Keniry, Andrew ; Ghori, Mohammed J.R. ; Schreiber, Stefan ; El Mokhtari, Nour Eddine ; Hall, Alistair S. ; Dixon, Richard J. ; Goodall, Alison H. ; Liptau, Henrike ; Pollard, Helen ; Schwarz, Daniel F. ; Hothorn, Ludwig A. ; Wichmann, H. -Erich ; König, Inke R. ; Fischer, Marcus ; Meisinger, Christa ; Ouwehand, Willem ; Deloukas, Panos ; Thompson, John R. ; Erdmann, Jeanette ; Ziegler, Andreas ; Samani, Nilesh J.



Zusammenfassung

Background - Recently, genome-wide association studies identified variants on chromosome 9p21.3 as affecting the risk of coronary artery disease (CAD). We investigated the association of this locus with CAD in 7 case-control studies and undertook a meta-analysis. Methods and Results - A single-nucleotide polymorphism (SNP), rs1333049, representing the 9p21.3 locus, was genotyped in 7 case-control ...

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