Gross, Catharina ; Holler, Ernst ; Stangl, Stefan ; Dickinson, Anne ; Pockley, A. Graham 
; Asea, Alexzander A. ; Mallappa, Nagaraja ; Multhoff, Gabriele
Alternative Links zum Volltext:DOIVerlag
| Dokumentenart: | Artikel |
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| Titel eines Journals oder einer Zeitschrift: | Leukemia Research |
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| Verlag: | PERGAMON-ELSEVIER SCIENCE LTD |
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| Ort der Veröffentlichung: | OXFORD |
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| Band: | 32 |
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| Nummer des Zeitschriftenheftes oder des Kapitels: | 4 |
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| Seitenbereich: | S. 527-534 |
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| Datum: | 2008 |
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| Institutionen: | Medizin > Lehrstuhl für Innere Medizin III (Hämatologie und Internistische Onkologie) |
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| Identifikationsnummer: | | Wert | Typ |
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| 10.1016/j.leukres.2007.03.027 | DOI |
|
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| Stichwörter / Keywords: | NATURAL-KILLER-CELLS; HEAT-SHOCK-PROTEIN; BONE-MARROW TRANSPLANTATION; HUMAN TUMOR-CELLS; CYTOLYTIC ACTIVITY; SURFACE EXPRESSION; THERAPY; CANCER; LYMPHOCYTES; hsp70 peptide TKD; HLA-E; NK cells; stem cell transplantation; cytotoxicity |
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| Dewey-Dezimal-Klassifikation: | 600 Technik, Medizin, angewandte Wissenschaften > 610 Medizin |
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| Status: | Veröffentlicht |
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| Begutachtet: | Ja, diese Version wurde begutachtet |
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| An der Universität Regensburg entstanden: | Ja |
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| Dokumenten-ID: | 68269 |
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Web of Science
Zusammenfassung
In contrast to solid tumors, leukemic blasts frequently present both Hsp70 and HLA-E on their cell Surface and thereby present activating and inhibitory signals to CD94(+) NK cells. In the first 12 months after stem cell trail splantation (SCT) CD94(+) NK cells clearly dominate over CD3(+)/CD16(-)/56(-) T and CD3(+)/CD16(+)/56(+) NK-like T cells. An incubation of post-SCT-derived peripheral blood ...
Zusammenfassung
In contrast to solid tumors, leukemic blasts frequently present both Hsp70 and HLA-E on their cell Surface and thereby present activating and inhibitory signals to CD94(+) NK cells. In the first 12 months after stem cell trail splantation (SCT) CD94(+) NK cells clearly dominate over CD3(+)/CD16(-)/56(-) T and CD3(+)/CD16(+)/56(+) NK-like T cells. An incubation of post-SCT-derived peripheral blood lymphocytes with the Hsp70 peptide TKD and IL-15 enhances the cell surface density of CD56/CD94 and initiates the cytolytic activity of NK cells against Hsp70/HLA-E double-positive autologous and allogeneic leukemic blasts. Hsp70 was identified as the target structure for TKD-activated NK cells. (C) 2007 Elsevier Ltd. All rights reserved.
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