Hiller, A. ; Fischer, C. ; Jordanova, A. ; Patt, J.T. ; Steinbach, J. 
Alternative Links zum Volltext:DOIVerlag
| Dokumentenart: | Artikel |
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| Titel eines Journals oder einer Zeitschrift: | Applied Radiation and Isotopes |
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| Verlag: | PERGAMON-ELSEVIER SCIENCE LTD |
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| Ort der Veröffentlichung: | OXFORD |
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| Band: | 66 |
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| Nummer des Zeitschriftenheftes oder des Kapitels: | 2 |
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| Seitenbereich: | S. 152-157 |
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| Datum: | 2008 |
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| Institutionen: | Medizin > Abteilung für Nuklearmedizin |
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| Identifikationsnummer: | | Wert | Typ |
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| 10.1016/j.apradiso.2007.08.016 | DOI |
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| Stichwörter / Keywords: | PERCHLORYL FLUORIDE; CLO3F; fluorine-18; perchloryl fluoride; electrophilic fluorination; no carrier added |
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| Dewey-Dezimal-Klassifikation: | 600 Technik, Medizin, angewandte Wissenschaften > 610 Medizin |
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| Status: | Veröffentlicht |
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| Begutachtet: | Ja, diese Version wurde begutachtet |
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| An der Universität Regensburg entstanden: | Ja |
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| Dokumenten-ID: | 68398 |
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Web of Science
Zusammenfassung
An approach to synthesize the electrophilic fluorinating agent no-carrier-added (n.c.a.) [F-18]perchloryl fluoride ([F-18]FClO3) in superacidic media in the presence of KClO4 or anhydrous perchloric acid starting from [F-18]fluoride was demonstrated in this study. However. the radiochemical yields were low (1-6%) and poorly reproducible. Fluorosulphonic acid proved to be an essential intermediate ...
Zusammenfassung
An approach to synthesize the electrophilic fluorinating agent no-carrier-added (n.c.a.) [F-18]perchloryl fluoride ([F-18]FClO3) in superacidic media in the presence of KClO4 or anhydrous perchloric acid starting from [F-18]fluoride was demonstrated in this study. However. the radiochemical yields were low (1-6%) and poorly reproducible. Fluorosulphonic acid proved to be an essential intermediate as revealed by non-radioactive experiments. A key problem in the preparation of [F-18]FClO3 is the assumed kinetic inhibition due to the unfavourable stoichiometric ratio of the ClO4 moiety to [F-18]HSO3F. (C) 2007 Elsevier Ltd. All rights reserved.
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