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Loss of nephronectin promotes tumor progression in malignant melanoma

Kuphal, Silke ; Wallner, Susanne ; Bosserhoff, Anja K.



Zusammenfassung

Nephronectin (POEM) was originally identified as a factor involved in tissue morphogenesis. POEM has several characteristics of a matrix protein including an arg-gly-asp binding domain site that is recognized by integrins. Recently, deregulation of POEM was found in breast cancer. We therefore speculate that deregulation of POEM expression plays a role in the development or progression of ...

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