Berghof, L. ; Bolle, I. ; Schulz, A. ; Grifka, J. ; Quint, U.
Alternative Links zum Volltext:DOIVerlag
| Dokumentenart: | Artikel |
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| Titel eines Journals oder einer Zeitschrift: | Zeitschrift für Orthopädie und Unfallchirurgie |
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| Verlag: | THIEME MEDICAL PUBL INC |
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| Ort der Veröffentlichung: | NEW YORK |
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| Band: | 146 |
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| Nummer des Zeitschriftenheftes oder des Kapitels: | 01 |
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| Seitenbereich: | S. 70-74 |
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| Datum: | 2008 |
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| Institutionen: | Medizin > Lehrstuhl für Orthopädie |
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| Identifikationsnummer: | | Wert | Typ |
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| 10.1055/s-2007-989393 | DOI |
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| Stichwörter / Keywords: | SPINAL-FUSION; INSTRUMENTATION; VITRO; CELLS; interbody fusion; PLIF; ALIF; autogenous osteoblasts; cancellous bone |
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| Dewey-Dezimal-Klassifikation: | 600 Technik, Medizin, angewandte Wissenschaften > 610 Medizin |
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| Status: | Veröffentlicht |
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| Begutachtet: | Ja, diese Version wurde begutachtet |
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| An der Universität Regensburg entstanden: | Ja |
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| Dokumenten-ID: | 68621 |
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Web of Science
Zusammenfassung
Aim: In the present study we have investigated the potential of autogenous osteoblasts for osteoinduction in a spinal arthrodesis model. Method: After posterolateral instrumentation of 3 segments of a sheep spine the intervertebral space was filled with cancellous bone, osteoblasts OF left empty after nucleotomy and elimination of cartilage. Results: Radiological and histological analyses proved ...
Zusammenfassung
Aim: In the present study we have investigated the potential of autogenous osteoblasts for osteoinduction in a spinal arthrodesis model. Method: After posterolateral instrumentation of 3 segments of a sheep spine the intervertebral space was filled with cancellous bone, osteoblasts OF left empty after nucleotomy and elimination of cartilage. Results: Radiological and histological analyses proved a significant osseous reaction in segments treated with cancellous bone or osteoblasts in contrast to the control segment. This outcome provides evidence of spondylodeses by spinal instrumentation in combination with osteoblasts in a sheep model. Conclusion: The results suggest a possible application of autologous osteoblasts as an osteoinductor after percutaneous nucleotomy in spinal fusion. The possible application in a human model should be examined.
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