Zusammenfassung
Over one-third of patients with Crohn's disease eventually will develop intestinal stenosis with the need for surgical intervention. While the pathophysiology of the inflammatory response in Crohn's disease has been investigated extensively, the knowledge of intestinal fibrogenesis is limited. Fibrotic organ remodelling results from a complex interplay of genetic factors, acute and chronic ...
Zusammenfassung
Over one-third of patients with Crohn's disease eventually will develop intestinal stenosis with the need for surgical intervention. While the pathophysiology of the inflammatory response in Crohn's disease has been investigated extensively, the knowledge of intestinal fibrogenesis is limited. Fibrotic organ remodelling results from a complex interplay of genetic factors, acute and chronic inflammation, activation of mesenchymal cells and the timely expression of several proinflammatory and profibrotic cytokines. The combination of those factors leads to enhanced deposition of extracellular matrix with consecutive fibrosis of the intestine. Through investigation of the pathophysiologic processes of the fibrogenesis in Crohn's disease the basis for specific antifibrotic therapies can be built.
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