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A systematic survey evaluating 6-thioguanine-related hepatotoxicity in patients with inflammatory bowel disease

Teml, Alexander ; Schwab, Matthias ; Hommes, Daan W. ; Almer, Sven ; Lukas, Milan ; Feichtenschlager, Thomas ; Florin, Timothy ; Seiderer, Julia ; Petritsch, Wolfgang ; Bokemeyer, Bernd ; Kreisel, Wolfgang ; Herrlinger, Klaus R. ; Knoflach, Peter ; Bonaz, Bruno ; Klugmann, Thomas ; Herfarth, Hans ; Pedarnig, Nikolaus ; Reinisch, Walter



Zusammenfassung

OBJECTIVE: Drug-induced liver injury was recently reported as a major complication leading to hepatic nodular regenerative hyperplasia (NRH) in patients with inflammatory bowel disease (IBD) and 6-thioguanine (6-TG) therapy. The aim of the study was to evaluate the prevalence of 6-TG-related hepatotoxicity in a large multi-centered IBD population by means of a systematic online survey. METHODS: ...

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