Hafner, Christian ; Hartmann, Arndt ; Real, Francisco X. 
; Hofstaedter, Ferdinand ; Landthaler, Michael ; Vogt, Thomas
Alternative Links zum Volltext:DOIVerlag
| Dokumentenart: | Artikel |
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| Titel eines Journals oder einer Zeitschrift: | Journal of Investigative Dermatology |
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| Verlag: | NATURE PUBLISHING GROUP |
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| Ort der Veröffentlichung: | NEW YORK |
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| Band: | 127 |
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| Nummer des Zeitschriftenheftes oder des Kapitels: | 8 |
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| Seitenbereich: | S. 1883-1885 |
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| Datum: | 2007 |
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| Institutionen: | Medizin > Lehrstuhl für Dermatologie und Venerologie |
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| Identifikationsnummer: | | Wert | Typ |
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| 10.1038/sj.jid.5700804 | DOI |
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| Stichwörter / Keywords: | BENIGN SKIN TUMORS; ACTIVATING MUTATIONS; GROWTH; BLADDER; CRANIOSYNOSTOSIS; ACHONDROPLASIA; FREQUENCY; EXPOSURE; SUNLIGHT; |
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| Dewey-Dezimal-Klassifikation: | 600 Technik, Medizin, angewandte Wissenschaften > 610 Medizin |
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| Status: | Veröffentlicht |
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| Begutachtet: | Ja, diese Version wurde begutachtet |
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| An der Universität Regensburg entstanden: | Ja |
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| Dokumenten-ID: | 68975 |
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Web of Science
Zusammenfassung
Somatic FGFR3 mutations have recently been identified in seborrheic keratoses (SK). Affected individuals often show a large number of SK, but their spectrum of FGFR3 mutations has not been investigated yet. We analyzed 78 SK of four patients using a SNaPshot multiplex assay. FGFR3 mutations were detected in 46 of 78 SK (59%). The mutation rates of the patients ranged from 26 to 89%. Each patient ...
Zusammenfassung
Somatic FGFR3 mutations have recently been identified in seborrheic keratoses (SK). Affected individuals often show a large number of SK, but their spectrum of FGFR3 mutations has not been investigated yet. We analyzed 78 SK of four patients using a SNaPshot multiplex assay. FGFR3 mutations were detected in 46 of 78 SK (59%). The mutation rates of the patients ranged from 26 to 89%. Each patient showed at least four different mutated loci. FGFR3 mutations appear to be common genetic alterations in multiple SK with a varying interindividual mutation frequency but without specific intraindividual hot spots.
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