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Cell cycle phase distribution analysis in chronic lymphocytic leukaemia: a significant number of cells reside in early G1-phase

Obermann, Ellen C ; Went, Philip ; Tzankov, Alexandar ; Pileri, Stefano A ; Hofstaedter, Ferdinand ; Marienhagen, Joerg ; Stoehr, Robert ; Dirnhofer, Stephan



Zusammenfassung

Background and Aims: Chronic lymphocytic leukaemia (CLL) is a frequent non-Hodgkin lymphoma characterised by a heterogeneous clinical course. Assessment of cell cycle phase kinetics might be important for prediction of clinical behaviour and prognosis. Methods: Distribution of neoplastic cells in CLL within the cell cycle was evaluated by determining the labelling indices (LI, i.e. percentage of ...

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