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Podocin and MEC-2 bind cholesterol to regulate the activity of associated ion channels

Huber, Tobias B. ; Schermer, Bernhard ; Müller, Roman Ulrich ; Höhne, Martin ; Bartram, Malte ; Calixto, Andrea ; Hagmann, Henning ; Reinhardt, Christian ; Koos, Fabienne ; Kunzelmann, Karl ; Shirokova, Elena ; Krautwurst, Dietmar ; Harteneck, Christian ; Simons, Matias ; Pavenstädt, Hermann ; Kerjaschki, Dontscho ; Thiele, Christoph ; Walz, Gerd ; Chalfie, Martin ; Benzing, Thomas



Zusammenfassung

The prohibitin (PHB)-domain proteins are membrane proteins that regulate a variety of biological activities, including mechanosensation, osmotic homeostasis, and cell signaling, although the mechanism of this regulation is unknown. We have studied two members of this large protein family, MEC-2, which is needed for touch sensitivity in Caenorhabditis elegans, and Poclocin, a protein involved in ...

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