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Programmable implants—From pulsatile to controlled release

Guse, C. ; Koennings, S. ; Blunk, T. ; Siepmann, J. ; Goepferich, A.



Zusammenfassung

The aim of this study was to develop programmable implants with a reproducible delayed onset of release followed by several weeks of controlled release. For this purpose, a drug-loaded core was embedded into a drug-free bulk-eroding poly(D,L lactic-co-glycolic acid) or poly(D,L lactic acid) mantle. The manufacturing procedure was established and optimized for three mantle materials, which showed ...

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