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Zinc finger protein 267 is up-regulated during the activation process of human hepatic stellate cells and functions as a negative transcriptional regulator of MMP-10

Schnabl, Bernd ; Hu, Kanghong ; Mühlbauer, Marcus ; Hellerbrand, Claus ; Stefanovic, Branko ; Brenner, David A. ; Schölmerich, Jürgen



Zusammenfassung

Activation of hepatic stellate cells (HSCs) is the central event in the development of liver fibrosis and cirrhosis. The transdifferentiation process of quiescent into activated HSCs requires a complete reprogramming in gene expression, which is governed by modulation of transcriptional activators or repressors. Using microarray analysis to identify genes differentially expressed during the ...

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