| Dokumentenart: | Artikel | ||||
|---|---|---|---|---|---|
| Titel eines Journals oder einer Zeitschrift: | Thrombosis and Haemostasis | ||||
| Verlag: | GEORG THIEME VERLAG KG | ||||
| Ort der Veröffentlichung: | STUTTGART | ||||
| Band: | 94 | ||||
| Nummer des Zeitschriftenheftes oder des Kapitels: | 07 | ||||
| Seitenbereich: | S. 88-92 | ||||
| Datum: | 2005 | ||||
| Institutionen: | Medizin > Lehrstuhl für Kinder- und Jugendmedizin | ||||
| Identifikationsnummer: |
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| Stichwörter / Keywords: | FACTOR-XIII GENE; MOLECULAR-WEIGHT HEPARIN; ANTITHROMBOTIC PROPHYLAXIS; PREGNANCY COMPLICATIONS; VENOUS THROMBOSIS; VAL34LEU POLYMORPHISM; FACTOR-VII; COMMON POLYMORPHISM; MEDICAL PROGRESS; WOMEN; preterm delivery; coagulation system; factorVII/factor XIII | ||||
| Dewey-Dezimal-Klassifikation: | 600 Technik, Medizin, angewandte Wissenschaften > 610 Medizin | ||||
| Status: | Veröffentlicht | ||||
| Begutachtet: | Ja, diese Version wurde begutachtet | ||||
| An der Universität Regensburg entstanden: | Ja | ||||
| Dokumenten-ID: | 70655 |
Web of ScienceZusammenfassung
Clinical trials evaluating the potential benefit of anticoagulant treatment in pregnant women with inherited thrombophilia are based on the observation that a genetic predisposition to thrombosis is associated with frequent abortions and preterm birth. It was the aim of our study to delineate the impact of genetic polymorphisms with prothrombotic and antithrombotic effects on the occurrence of ...
Zusammenfassung
Clinical trials evaluating the potential benefit of anticoagulant treatment in pregnant women with inherited thrombophilia are based on the observation that a genetic predisposition to thrombosis is associated with frequent abortions and preterm birth. It was the aim of our study to delineate the impact of genetic polymorphisms with prothrombotic and antithrombotic effects on the occurrence of preterm birth in a large cohort of very-low-birth-weight (VLBW)-infants and their mothers. We examined the factor V Leiden and the prothrombin G20210A mutation, the factor VII 121 del/ins and the factor XIII Val34Leu polymorphism in preterm very-low-birth-weight (VLBW, n=593) and term-born-infants (n=278) and their mothers (n=785). The primary outcome was preterm vs.term birth. From all polymorphisms tested, the maternal factor VII-121 del/ins polymorphism (26.2 vs. 17.6 %; p=0.009) and the infant's factor VII-121 del/ins polymorphism (29.0 vs. 20.0 %; p=0.009) were more frequent in singleton VLBW and their mothers compared to term infants and their mothers. Furthermore, the frequency of the factor XIlI-Val34Leu polymorphism was significantly lower in singleton VLBW than in term infant controls (5.1 vs. 9.6%, p=0.025). In a multivariate regression analysis, previous preterm delivery (OR=3.8, 95% Cl: 1.7-8.4), the maternal carrier status of the factor-VII-121 del/ins polymorphism (OR=1.7, 95% Cl: 1.12-2.5, p=0.007) and the lower frequency of infant's factor-XIII-Val34Leu polymorphism (OR=0.53; 95% Cl: 0.29-0.96; p=0.038) were found to be independently associated with preterm delivery. InVLBW mothers with pathological CTG as cause of preterm delivery, the frequency of factorV Leiden mutation was significantly increased compared to VLBW mothers without pathological CTG (14.1 vs. 6.1%, p=0.01). The investigated haemostasis gene polymorphisms have a much lower impact on subsequent preterm delivery than known risk factors such as previous preterm birth. The reported association of the factor-VII-121 del/ins polymorphism on preterm delivery and its clinical relevance needs to be further elucidated.
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