Pongratz, Georg 
; Härle, Peter ; Schnellinger, Georg ; Janele, David ; Schölmerich, Jürgen ; Straub, Rainer H.
Alternative Links zum Volltext:DOIVerlag
| Dokumentenart: | Artikel |
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| Titel eines Journals oder einer Zeitschrift: | Journal of Neuroimmunology |
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| Verlag: | ELSEVIER SCIENCE BV |
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| Ort der Veröffentlichung: | AMSTERDAM |
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| Band: | 158 |
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| Nummer des Zeitschriftenheftes oder des Kapitels: | 1-2 |
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| Seitenbereich: | S. 120-127 |
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| Datum: | 2005 |
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| Institutionen: | Medizin > Lehrstuhl für Innere Medizin I |
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| Identifikationsnummer: | | Wert | Typ |
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| 10.1016/j.jneuroim.2004.08.017 | DOI |
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| Stichwörter / Keywords: | PITUITARY-ADRENAL AXIS; TUMOR-NECROSIS-FACTOR; GLUCOCORTICOID-RECEPTOR; INTERLEUKIN-6 SECRETION; PLASMA INTERLEUKIN-6; CIRCADIAN-RHYTHMS; RHEUMATOID-ARTHRITIS; ADRENERGIC-RECEPTORS; BIOLOGICAL CLOCK; EPITHELIAL-CELLS; IL-6; spleen; daytime-dependent IL-6 release; corticosterone; norepinephrine |
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| Dewey-Dezimal-Klassifikation: | 600 Technik, Medizin, angewandte Wissenschaften > 610 Medizin |
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| Status: | Veröffentlicht |
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| Begutachtet: | Ja, diese Version wurde begutachtet |
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| An der Universität Regensburg entstanden: | Ja |
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| Dokumenten-ID: | 71058 |
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Web of Science
Zusammenfassung
In early morning hours, a rise of serum cytokines such as IL-6 was described. This study aimed to find reasons for this phenomenon focussing on NE and corticosterone. Mouse spleen slices were electrically stimulated (ES) in a microsuperfusion chamber in order to release endogenous NE. ES inhibited IL-6 secretion when animals were sacrificed at 03:00 and 06:00 (both p < 0.001) but it increased its ...
Zusammenfassung
In early morning hours, a rise of serum cytokines such as IL-6 was described. This study aimed to find reasons for this phenomenon focussing on NE and corticosterone. Mouse spleen slices were electrically stimulated (ES) in a microsuperfusion chamber in order to release endogenous NE. ES inhibited IL-6 secretion when animals were sacrificed at 03:00 and 06:00 (both p < 0.001) but it increased its secretion from spleen slice removed at 09:00 (p = 0.026). Prior administration of corticosterone or the glucocorticoid antagonist RU486 abrogated these ES effects. Endogenous NE via alpha- and beta-adrenoceptors mediated this time-dependent differential effects. This study demonstrates that cooperation of endogenous NE and corticosterone are involved in a time-dependent fall or rise of splenic IL-6 secretion. (C) 2004 Elsevier B.V. All rights reserved.
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