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Inhibition of Src Tyrosine Kinase as Treatment for Human Pancreatic Cancer Growing Orthotopically in Nude Mice

Yezhelyev, Maksim V. ; Koehl, Gudrun ; Guba, Markus ; Brabletz, Thomas ; Jauch, Karl-Walter ; Ryan, Anderson ; Barge, Alan ; Green, Tim ; Fennell, Michael ; Bruns, Christiane J.



Zusammenfassung

Purpose: The Src family comprises a family of nonreceptor intracellular tyrosine kinases that mediate a variety of cellular pathways. Src kinases are overexpressed in a variety of human tumors, including cancer of the colon, breast, and pancreas, and they are an integral part of tumor cell signaling pathways associated with migration, proliferation, adhesion, and angiogenesis. Experimental ...

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