Abstract
We describe the kindred of Alois Alzheimer's second patient, who died from plaque-only Alzheimer's disease (AD) in 1910. There is a neuropathologically defined subtype of AD without or only few tangles. This plaque-only form is found in about 6% of autopsied cases of AD. We recruited of AD patients with age of onset before 70 years from the Rottal-Inn and Passau counties in Bavaria and extended a ...
Abstract
We describe the kindred of Alois Alzheimer's second patient, who died from plaque-only Alzheimer's disease (AD) in 1910. There is a neuropathologically defined subtype of AD without or only few tangles. This plaque-only form is found in about 6% of autopsied cases of AD. We recruited of AD patients with age of onset before 70 years from the Rottal-Inn and Passau counties in Bavaria and extended a kindred with familial dementia using genealogies deduced from historic parish records. 1247 individuals were documented genealogically. In the maternal branch of the kindred we documented 40 deceased individuals with possible Alzheimer's disease, whereas other branches of the family had no suspicious entries. We conclude, that there is a familial predisposition to dementia with variable age of onset between 36 and 80 years of age in the kindred of Johann F.
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