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Maintenance Therapy with 13-cis Retinoid Acid in High-Grade Glioma at Complete Response After First-Line Multimodal Therapy – A Phase-II Study

Wismeth, Caecilia ; Hau, Peter ; Fabel, Klaus ; Baumgart, Ulrike ; Hirschmann, Birgit ; Koch, Horst ; Jauch, Tanja ; Grauer, Oliver ; Drechsel, Lisa ; Brawanski, Alexander ; Bogdahn, Ulrich ; Steinbrecher, Andreas



Zusammenfassung

Background: Approximately 5% of patients with malignant glioma achieve complete response (CR) after first-line combined modality treatment. Although these patients will invariably suffer from tumor recurrence, they usually do not receive any further treatment to maintain remission. According to in vitro and in vivo clinical studies, 13-cis retinoic acid (cRA) may be a promising agent for ...

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