Hypoxia up-regulates triosephosphate isomerase expression via a HIF-dependent pathway

Gess, Bernhard ; Hofbauer, Karl-Heinz ; Deutzmann, R. ; Kurtz, Armin

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Zusammenfassung

The glycolytic enzyme triosephosphate isomerase (TPI) catalyses the reversible conversion of dihydroxyacetone phosphate into glyceraldehyde-3-phosphate. We report here that the expression of TPI at both the mRNA and protein levels is increased by hypoxia in vivo and in vitro. The temporal pattern of hypoxic TPI induction is very similar to that of genes triggered by the hypoxia-inducible ...