Hartmann, P. ; Herholz, K. ; Salzberger, B. ; Petereit, H. F.
Alternative Links zum Volltext:DOIVerlag
| Dokumentenart: | Artikel |
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| Titel eines Journals oder einer Zeitschrift: | Annals of Hematology |
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| Verlag: | SPRINGER |
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| Ort der Veröffentlichung: | NEW YORK |
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| Band: | 83 |
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| Nummer des Zeitschriftenheftes oder des Kapitels: | 4 |
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| Seitenbereich: | S. 212-217 |
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| Datum: | 2004 |
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| Institutionen: | Medizin > Lehrstuhl für Innere Medizin I |
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| Identifikationsnummer: | | Wert | Typ |
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| 10.1007/s00277-003-0802-2 | DOI |
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| Stichwörter / Keywords: | COLONY-STIMULATING FACTOR; PHASE-II TRIAL; QUALITY-OF-LIFE; G-CSF; GLIOBLASTOMA-MULTIFORME; INTERFERON-GAMMA; IN-VITRO; GM-CSF; ANAPLASTIC ASTROCYTOMA; ASPERGILLUS-FUMIGATUS; neutrophils; temozolomide; malignant glioma; drug effects; immunology |
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| Dewey-Dezimal-Klassifikation: | 600 Technik, Medizin, angewandte Wissenschaften > 610 Medizin |
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| Status: | Veröffentlicht |
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| Begutachtet: | Ja, diese Version wurde begutachtet |
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| An der Universität Regensburg entstanden: | Ja |
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| Dokumenten-ID: | 71637 |
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Web of Science
Zusammenfassung
Temozolomide, a recently approved cytotoxic agent for the treatment of malignant glioma, has shown promising results in the treatment studies published so far. However, cytopenia and related infectious complications have been reported in 2-8% of cases. Here we present three treatment-naive patients with malignant glioma experiencing cytopenia and/or infectious complications after the first cycle ...
Zusammenfassung
Temozolomide, a recently approved cytotoxic agent for the treatment of malignant glioma, has shown promising results in the treatment studies published so far. However, cytopenia and related infectious complications have been reported in 2-8% of cases. Here we present three treatment-naive patients with malignant glioma experiencing cytopenia and/or infectious complications after the first cycle of temozolomide. Neutrophils obtained from each patient up to 6 weeks after the end of the temozolomide application showed normal phagocytic capacity but decreased oxygen radical production and thus impairment of microcidal activity. Our data suggest that a prolonged impairment of the immunological defense may occur in temozolomide-treated patients.
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