Bosserhoff, Anja K. 
; Buettner, Reinhard
Alternative Links zum Volltext:DOIVerlag
| Dokumentenart: | Artikel |
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| Titel eines Journals oder einer Zeitschrift: | Biomaterials |
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| Verlag: | ELSEVIER SCI LTD |
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| Ort der Veröffentlichung: | OXFORD |
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| Band: | 24 |
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| Nummer des Zeitschriftenheftes oder des Kapitels: | 19 |
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| Seitenbereich: | S. 3229-3234 |
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| Datum: | 2003 |
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| Institutionen: | Medizin > Lehrstuhl für Pathologie |
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| Identifikationsnummer: | | Wert | Typ |
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| 10.1016/S0142-9612(03)00184-4 | DOI |
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| Stichwörter / Keywords: | ACID-SENSITIVE PROTEIN; MALIGNANT-MELANOMA; SERUM MARKER; CARTILAGE; EXPRESSION; COLLAGEN; CLONING; GENE; MIA; CD-RAP; chondrocyte; differentiation; tissue engineering |
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| Dewey-Dezimal-Klassifikation: | 600 Technik, Medizin, angewandte Wissenschaften > 610 Medizin |
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| Status: | Veröffentlicht |
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| Begutachtet: | Ja, diese Version wurde begutachtet |
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| An der Universität Regensburg entstanden: | Ja |
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| Dokumenten-ID: | 72129 |
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Web of Science
Zusammenfassung
Melanoma inhibitory activity (MIA), also referred to as cartilage derived retinoic acid-sensitive protein (CD-RAP), is detected physiologically in cartilage tissue and pathologically in malignant melanomas. To measure MIA/CD-RAP quantitatively we developed a sensitive ELISA system. Recently, we described diagnostic applications of the MIA-ELISA in patients with cartilage diseases. The study ...
Zusammenfassung
Melanoma inhibitory activity (MIA), also referred to as cartilage derived retinoic acid-sensitive protein (CD-RAP), is detected physiologically in cartilage tissue and pathologically in malignant melanomas. To measure MIA/CD-RAP quantitatively we developed a sensitive ELISA system. Recently, we described diagnostic applications of the MIA-ELISA in patients with cartilage diseases. The study described herein was performed to determine whether there is any relation between MIA/CD-RAP levels and the degree of chondrocyte differentiation in tissue culture and to analyse whether MIA/CD-RAP may serve as a useful marker to control chondrocyte differentiation in in vitro tissue engineering. Our data provide evidence that measuring MIA in tissue culture supernatant by a quantitative ELISA can be used as a marker for differentiated chondrocytes. (C) 2003 Elsevier Science Ltd. All rights reserved.
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