| Dokumentenart: | Artikel | ||||
|---|---|---|---|---|---|
| Titel eines Journals oder einer Zeitschrift: | Arthritis & Rheumatism | ||||
| Verlag: | WILEY-LISS | ||||
| Ort der Veröffentlichung: | NEW YORK | ||||
| Band: | 48 | ||||
| Nummer des Zeitschriftenheftes oder des Kapitels: | 7 | ||||
| Seitenbereich: | S. 1939-1947 | ||||
| Datum: | 2003 | ||||
| Institutionen: | Medizin > Lehrstuhl für Innere Medizin I Medizin > Lehrstuhl für Medizinische Mikrobiologie und Hygiene | ||||
| Identifikationsnummer: |
| ||||
| Stichwörter / Keywords: | SYSTEMIC-LUPUS-ERYTHEMATOSUS; BETA-2-GLYCOPROTEIN-I APOLIPOPROTEIN-H; MOLECULAR MIMICRY; BONE-MARROW; ANTICARDIOLIPIN COFACTOR; CLINICAL MANIFESTATIONS; NONSTRUCTURAL PROTEIN; SYNOVIAL MEMBRANES; BLOOD-DONORS; P6 PROMOTER; | ||||
| Dewey-Dezimal-Klassifikation: | 600 Technik, Medizin, angewandte Wissenschaften > 610 Medizin | ||||
| Status: | Veröffentlicht | ||||
| Begutachtet: | Ja, diese Version wurde begutachtet | ||||
| An der Universität Regensburg entstanden: | Ja | ||||
| Dokumenten-ID: | 72180 |
Web of ScienceZusammenfassung
Objective. To show a possible association between parvovirus B19 infection and the presence of antiphos-pholipid antibodies (aPL) in patients with rheumatic diseases. Methods. Serum samples obtained from 88 children with various forms of juvenile rheumatic disease and from 40 adults with systemic lupus erythematosus, the antiphospholipid syndrome, or other rheumatic disease, who had previously ...
Zusammenfassung
Objective. To show a possible association between parvovirus B19 infection and the presence of antiphos-pholipid antibodies (aPL) in patients with rheumatic diseases. Methods. Serum samples obtained from 88 children with various forms of juvenile rheumatic disease and from 40 adults with systemic lupus erythematosus, the antiphospholipid syndrome, or other rheumatic disease, who had previously been tested and shown to be positive for IgG aPL, were analyzed for the presence of B19 DNA, for antibodies against the B19 viral proteins VP1, VP2, and NS1, and for IgG aPL (anticardiolipin, anti-beta2-glycoprotein I, and antiphosphatidyiserine). As controls, serum samples obtained from 135 children with noninflammatory bone diseases or growth retardation were also analyzed. Results. Twenty-four (27%) of the 88 children with rheumatic diseases had detectable amounts of IgG aPL. Fourteen (58%) of these 24 IgG aPL-positive patients showed IgG against VP1/VP2 and viral genomes, indicating the presence of acute (2 patients) persistent (12 patients) infection. Past parvovirus B19 infection was identified in 7 (29%) of 24 IgG aPL-positive children, as indicated by VP1/VP2-specific IgG in the absence of viral DNA. Three (12%) of 24 IgG aPL-positive children had not been infected with B19. Sixty-nine (51%) of 135 control children displayed VP1/ VP2-specific IgG. Three (2%) of these 135 children were IgG aPL positive (2 children had past parvovirus B19 infection, and I was negative for parvovirus B19). Analysis of the parvovirus B19 status of 40 adult IgG aPL-positive patients showed that 33 (83%) were anti-IgG VP1/VP2-positive, and viral DNA was detected in 11 patients (28%). Ten of these 11 viremic patients were in the subgroup of 28 IgG aPL-positive SLE patients. Conclusion. Antiphospholipid antibodies are preferentially found in serum of children with juvenile idiopathic arthritis who have been previously infected with parvovirus B19 and have established, persistent infection. Adult patients with IgG aPL positivity have a high incidence of persistent parvovirus B19 infection. We conclude that parvovirus B19 might be directly involved in the elicitation of autoimmune reactions partly mediated by aPL.
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