Alternative Links zum Volltext:DOIVerlag
| Dokumentenart: | Artikel |
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| Titel eines Journals oder einer Zeitschrift: | European Journal of Gastroenterology & Hepatology |
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| Verlag: | LIPPINCOTT WILLIAMS & WILKINS |
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| Ort der Veröffentlichung: | PHILADELPHIA |
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| Band: | 15 |
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| Nummer des Zeitschriftenheftes oder des Kapitels: | 6 |
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| Seitenbereich: | S. 615-620 |
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| Datum: | 2003 |
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| Institutionen: | Medizin > Lehrstuhl für Innere Medizin I |
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| Identifikationsnummer: | | Wert | Typ |
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| 10.1097/00042737-200306000-00006 | DOI |
|
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| Stichwörter / Keywords: | INFLAMMATORY-BOWEL-DISEASE; RESIDENT INTESTINAL FLORA; HLA-B27 TRANSGENIC RATS; NORMAL LUMINAL BACTERIA; CROHNS-DISEASE; ULCERATIVE-COLITIS; DEFICIENT MICE; ESCHERICHIA-COLI; BACTEROIDES-VULGATUS; CHEMOTACTIC PEPTIDE; endogenous bacteria; inflammatory bowel disease; microbial factors; tolerance; antibiotics; probiotics |
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| Dewey-Dezimal-Klassifikation: | 600 Technik, Medizin, angewandte Wissenschaften > 610 Medizin |
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| Status: | Veröffentlicht |
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| Begutachtet: | Ja, diese Version wurde begutachtet |
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| An der Universität Regensburg entstanden: | Ja |
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| Dokumenten-ID: | 72240 |
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Web of Science
Zusammenfassung
Abundant experimental and clinical data incriminate microbial factors in the pathogenesis of inflammatory bowel diseases. Commensal bacteria, and their products, provide the constant antigenic stimulus to disequilibrate the mucosal immune system towards an overly aggressive response in a genetically susceptible host with reduced tolerance towards the autologous flora. Not all bacteria have equal ...
Zusammenfassung
Abundant experimental and clinical data incriminate microbial factors in the pathogenesis of inflammatory bowel diseases. Commensal bacteria, and their products, provide the constant antigenic stimulus to disequilibrate the mucosal immune system towards an overly aggressive response in a genetically susceptible host with reduced tolerance towards the autologous flora. Not all bacteria have equal proinflammatory capabilities. Some may be even beneficial as demonstrated by the anti-inflammatory effects of so-called probiotics. Further investigations are needed to translate the clear experimental and clinical evidence into benefit for the patients. (C) 2003 Lippincott Williams Wilkins.
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