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Mature But Not Immature Fas Ligand (CD95L)-Transduced Human Monocyte-Derived Dendritic Cells Are Protected from Fas-Mediated Apoptosis and Can Be Used as Killer APC

Hoves, Sabine ; Krause, Stefan W. ; Halbritter, Dagmar ; Zhang, Huang-Ge ; Mountz, John D. ; Schölmerich, Jürgen ; Fleck, Martin



Zusammenfassung

Several in vitro and animal studies have been performed to modulate the interaction of APCs and T cells by Fas (CD95/Apo-1) signaling to delete activated T cells in an Ag-specific manner. However, due to the difficulties in vector generation and low transduction frequencies, similar studies with primary human APC are still lacking. To evaluate whether Fas ligand (FasL/ CD95L) expressing killer ...

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