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Alternative Links zum Volltext:DOIVerlag
| Dokumentenart: | Artikel |
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| Titel eines Journals oder einer Zeitschrift: | Journal of Neurology |
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| Verlag: | DR DIETRICH STEINKOPFF VERLAG |
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| Ort der Veröffentlichung: | DARMSTADT |
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| Band: | 250 |
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| Nummer des Zeitschriftenheftes oder des Kapitels: | 5 |
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| Seitenbereich: | S. 542-545 |
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| Datum: | 2003 |
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| Institutionen: | Medizin > Lehrstuhl für Neurologie |
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| Identifikationsnummer: | | Wert | Typ |
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| 10.1007/s00415-003-1032-1 | DOI |
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| Stichwörter / Keywords: | LAMOTRIGINE; MECHANISMS; ANALOG; trigeminal neuralgia; misoprostol; multiple sclerosis |
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| Dewey-Dezimal-Klassifikation: | 600 Technik, Medizin, angewandte Wissenschaften > 610 Medizin |
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| Status: | Veröffentlicht |
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| Begutachtet: | Ja, diese Version wurde begutachtet |
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| An der Universität Regensburg entstanden: | Ja |
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| Dokumenten-ID: | 72294 |
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Web of Science
Zusammenfassung
Multiple sclerosis can be associated with trigeminal neuralgia which is often difficult to treat in this specific condition. We performed an open prospective trial on the efficacy and safety of the prostaglandin-E-1-analogue misoprostol (600 mug per day) in the reduction of attack frequency and pain intensity in patients with refractory trigeminal neuralgia associated with multiple sclerosis. ...
Zusammenfassung
Multiple sclerosis can be associated with trigeminal neuralgia which is often difficult to treat in this specific condition. We performed an open prospective trial on the efficacy and safety of the prostaglandin-E-1-analogue misoprostol (600 mug per day) in the reduction of attack frequency and pain intensity in patients with refractory trigeminal neuralgia associated with multiple sclerosis. Eighteen patients completed the study period and 14 of them showed a reduction of more than 50% in attack frequency and intensity beginning five days after treatment onset. There were only mild and transient drug related side effects in three patients. One patient stopped taking misoprostol after the study period because of severe menorrhagia. Our results suggest that misoprostol is effective and safe in the treatment of this specific type of refractory trigeminal neuralgia.
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