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Acylation of peptides by lactic acid solutions

Lucke, A



Zusammenfassung

To simplify the search for effective mechanisms to suppress peptide acylation inside drug delivery devices made Of poly(D,L-lactic acid) (PLA) and poly(lactic-co-glycolic acid), we were looking for a suitable model system that would allow screening of strategies for peptide stabilization. With their low pH and the presence of lactic acid oligomers, diluted lactic acid solutions promised to be a ...

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