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Carbonic anhydrase inhibitors: Two-prong versus mono-prong inhibitors of isoformsI, II, IX and XII exemplified by photochromics cis-1,2-a-dithienylethene derivates

Vomasta, Daniel ; Innocenti, A. ; König, Burkhard ; Supuran, T.



Abstract

We investigated the inhibition of five physiologically relevant CA isoforms with photochromic cis-1,2-adithienylethene- based compounds incorporating either a benzenesulfonamide and Cu(II)-iminodiacetic acid (IDA)-, bis-benzenesulfonamide-, bis-Cu(II)-IDA-, and bis-ethyleneglycol-methyl ether moieties, in both their open- and closed-ring forms. For hCA I the best inhibitors were the mono-prong ...

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